Searchable abstracts of presentations at key conferences in endocrinology

ea0070aep539 | Endocrine-related Cancer | ECE2020

Involvement of the splicing machinery in the antitumoral actions of metformin in prostate cancer

Montero-Hidalgo Antonio J. , Jiménez-Vacas Juan M. , Herrero-Aguayo Vicente , Sarmento-Cabral André , López Miguel , Castaño Justo P , Gahete Manuel D , Luque Raúl M

Metformin has recently emerged as a potential therapeutic tool for different tumour pathologies, including prostate cancer (PCa)1, one of the leading causes of cancer-deaths in men worldwide. However, the molecular mechanisms underlying the antitumor effects of metformin in PCa are not fully elucidated. In this context, previous reports have suggested a relationship between metformin and the process of alternative splicing in some cell-types. Nevertheless, the poten...